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Description
Cycloastragenol - 10 mg, 30 capsulesCycloastragenol is a bioactive molecule derived from Astragalus, a botanical widely used in Traditional Chinese Medicine and prized for its adaptogenic, immune supporting, and whole body benefits. Emerging evidence suggests cycloastragenol may unlock key aspects of healthy aging; it is known to support: Telomerase activation* Healthy telomere length* Healthy DNA structure* Antioxidant activity* Optimized aging at the genetic level* View Certificate of
Cycloastragenol is a bioactive molecule derived from Astragalus, a botanical widely used in Traditional Chinese Medicine and prized for its adaptogenic, immune-supporting, and whole-body benefits. Emerging evidence suggests cycloastragenol may unlock key aspects of healthy aging; it is known to support:
- Telomerase activation*
- Healthy telomere length*
- Healthy DNA structure*
- Antioxidant activity*
- Optimized aging at the genetic level*
Research-Supported Benefits:
Supports telomere length and healthy aging. Telomere attrition is one of the hallmarks of aging. Telomeres are the protective caps of chromosomes and help protect them from degradation. Critically short telomeres have been associated with cellular senescence and other parts of the aging process. Cycloastragenol may help activate telomerase, the major enzyme responsible for maintaining telomere length.*Supports healthy cell cleanup and antioxidative status. Improvement in markers related to antioxidative status was observed in the presence of cycloastragenol in an animal study. Cycloastragenol was also shown to help support the elimination of senescent cells in another animal study.*
References:
Ikram M, Jo MH, Choe K, et al. Cells. 2021;10(10):2719.
Ip FCF, Ng YP, An HJ, et al. Neurosignals. 2014;22(1):52-63.
Zhang Y, Gao D, Yuan Y, et al. Int J Mol Sci. 2023;24(7):6554.
- May help activate telomerase, the major enzyme involved in adding back telomeric DNA to the ends of chromosomes, by regulating MAPK and Akt signaling pathways.*
- May help support cAMP response element binding (CREB) activation.* CREB helps regulate gene expression related to cell survival and replication in many cell types.
- May support antioxidant activity in the aging brain.*
| Supplement Facts | ||
|---|---|---|
| Serving Size: 1 Capsule |
||
| Servings Per Container: 30 |
||
| Amount Per Serving | %DV | |
| Cycloastragenol (from Astragalus membranaceus Extract) (root) |
10 mg | † |
| † Daily Value not established | ||
REV.06.24
- OTHER INGREDIENTS: Vegetable capsule, rice flour.
- DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shellfish, tree nuts, peanuts, sesame.
- SUGGESTED DAILY USE: Take one (1) capsule per day, or as directed by your healthcare professional.
-
NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper evident seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
-
CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
- Superior Absorption and Bioavailability. A pharmacokinetic study showed that cycloastragenol has superior absorption and bioavailability compared to astragaloside IV, the main active constituent in A. membranaceus. This is in part due to cycloastragenol's low molecular weight.
- Science-First Formulations: We source only the highest quality ingredients backed by validated research to help you achieve your longevity goals.
- Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
- Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
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4.8 ★★★★★
Based on 1518 reviews
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Product Reviews
★★★★★ 5
Truly indestructible!
My 80lb English bulldog, that literally can chew his way through a tree trunk if left to his own devices, has not been able to destroy this toy. Rather, he’s enjoyed chomping on it bc of the scent and heavy weight for more than a year. Good value and will hopefully last many more years.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 9, 2025
★★★★★ 4
Nice toy
Flavor Name: Peanut Butter, Size: Large
I bought this toy in L size for my Frenchie cuz he is a hard chewer, and it ended up being too big for him. He seemed to love it though. I’ll reorder a smaller size
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 11, 2026
★★★★★ 5
Great product
Durable, great for strong chewers, dog likes it, great for big dogs, looks just like photo, true to size stated
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 23, 2024
★★★★★ 1
The warnings on the box say it's dangerous, the product page said it was safe.
Besides being much smaller than expected, this is from the box:
+ It's important to select the proper size & type of chew for your dog's age, weight & chewing strength. - "The Amazon page says it's 'Safe for All Dog Sizes.'"
+ Always supervise the use of all chews & toys - "The Amazon page says 'a safe alternative to edible chews when you can’t be home.'"
+ Product is not intended to be eaten or ingested. If you think your dog swallowed a piece, take the product
away and contact your veterinarian. - "The Amazon page says it 'provides a safer alternative to real sticks. Safe non-toxic. A safe alternative to edible chews when you can’t be home."
I've been disappointed by Amazon purchases before, but this is the first negative review I've written because this thing seems dangerous for dogs. I would report it to Amazon, but I can't figure out how.
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Reviewed in the United States on August 26, 2022
★★★★★ 3
It's not for aggressive chewers.
Flavor Name: Peanut Butter, Size: Large
The bone looks solid except for the brown strip wrapped around it. My dog chewed a piece of it off and tried to swallow them. I had to pull two strips of hard plastic out of his mouth. I threw the bone away.
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Reviewed in the United States on February 2, 2026
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