TIMP-1 Protein, Mouse
SKU: 34859127660

TIMP-1 Protein, Mouse

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Description

TIMP-1 Protein, MouseProduct Specification Species Mouse Synonyms TIMP1, CLGI, TIMP Accession P12032 Amino Acid Sequence Cys25 Arg205, with C terminal His Tag Expression System HEK293 Molecular Weight 25 30kDa (Reducing) Purity 95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability &

Product Specification


Species Mouse
Synonyms TIMP1, CLGI, TIMP
Accession P12032
Amino Acid Sequence Cys25-Arg205, with C-terminal His Tag
Expression System HEK293
Molecular Weight

25-30kDa (Reducing)

Purity >95% by SDS-PAGE and HPLC.
Endotoxin <0.1EU/μg
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Hornebeck W. (2004) Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. Pathol Biol. 51(10): 569-573.
2、Soini Y. et al. (2001) Expression of MMP2, MMP9, MT1-MMP, TIMP-1, and TIMP2 mRNA in valvular lesions of the heart. J Pathol. 194(2): 225-231.

Background

TIMP metallopeptidase inhibitor 1 is also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. TIMP1 is a glycoprotein with a molecular mass of 28 kDa produced by a wide range of cell types. Tissue inhibitor matrix metalloproteinase 1 (TIMP1), which belongs to TIMP gene family, is a natural inhibitor of the matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinases 1 (TIMP1) was the secreted factor with the strongest male-biased expression in patient-derived pancreatic tumors. Male-specific up-regulation of systemic TIMP1 was demonstrated in PC mouse models and patients.

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SKU: 34859127660

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